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Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 416-428 doi: 10.1007/s11684-021-0838-5

Abstract: Given that these kinases play some roles in the progression of megakaryopoiesis, we speculate that abivertinib+ hematopoietic stem cells, Meg-01 cells, and C57BL/6 mice with abivertinib and observed megakaryopoiesisThese results suggested that megakaryopoiesis was inhibited by abivertinib.

Keywords: abivertinib     Btk inhibitor     platelet     megakaryocyte     megakaryopoiesis     thrombopoiesis    

Title Author Date Type Operation

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Journal Article